Paul Turner, Senior Associate
An ongoing space of examine considerations viral ecology, which addresses how viruses interact molecularly inside their hosts, between their hosts, and with their environment. In particular, Turner and his laboratory members have used both phages and viruses of eukaryotes as laboratory fashions for elucidating evolutionary rules of RNA virus emergence. Paul Turner is the Elihu Professor of Ecology and Evolutionary Biology at Yale University, and college member in Microbiology at Yale School of Medicine. He studies the evolutionary genetics of viruses, particularly bacteriophages that specifically infect bacterial pathogens, and RNA viruses that are vector-transmitted by mosquitoes.
Professor Turner works with colleagues at VECTOR to review the natural history and evolution of pathogenic RNA viruses such as Crimean Congo Hemorrhagic Fever. His non-analysis work focuses on development of human and laboratory capacity for diagnostic microbiology in low-useful resource settings. Turner makes a compelling case that viruses are more biologically profitable than mobile life, corresponding to in a 2013 evaluate that he coauthored . The article examines gauges of biological success, together with numerical abundance, environmental tolerance, kind biodiversity, reproductive potential, and widespread impact on other organisms.
Evolutionary Constraints Of Viruses
Paul Turner describes the basic biology of viruses, and provides an introduction to phage remedy, and the way it may be improved by making use of ‘evolution considering. Dr. Paul Turner is Professor of Ecology and Evolutionary Biology at Yale University, and holds an appointment within the Microbiology Program at Yale School of Medicine. His laboratory studies how viruses evolutionarily adapt to beat environmental challenges, corresponding to temperature modifications or infection of novel host species. Turner acquired his bachelor’s degree in Biology from the University of Rochester in 1988, and completed his graduate studies in microbial ecology and evolution at Michigan State University in 1995. Turner’s utilized analysis includes on the lookout for pure products that may be useful in combating essential pathogens.
The primary focus of Paul Turner’s analysis is to check the evolutionary genetics and genomics of microbes, especially the power of viruses to adapt to changes of their biotic and abiotic environments. These studies concern environmental challenges faced by viruses in any respect levels of biological group, including effects of changes in molecules, proteins, cells, populations, communities and ecosystems. His work is very interdisciplinary, using microbiology, computational biology, genomics, molecular biology and mathematical-modeling approaches, and especially experimental evolution (‘evolution-in-action’) studies underneath controlled laboratory situations. Turner makes use of a wide variety of RNA and DNA viruses in his studies, together with varied lytic, temperate and filamentous phages that infect bacteria.
In another research his team demonstrated that a historical past of prior RNA virus evolution in a number of hosts can foster the emergence of those viruses in novel hosts . Infectious diseases are prevalent in Cambodia, a rustic that’s struggling with poor infrastructure. Streptococcus pneumoniae causes probably the most extreme form of pneumonia and is now focused by the pneumococcal conjugate vaccine. Additionally, Turner’s group has demonstrated that viruses endure evolutionary commerce-offs across selective temperatures and throughout differing innate immune profiles of hosts.
- Paul Turner is the Elihu Professor of Ecology and Evolutionary Biology at Yale University, and faculty member in Microbiology at Yale School of Medicine.
- He additionally typically collaborates along with his graduate students and postdoctoral fellows, crediting his college students and mentees for his or her inspiration and assist over the years.
- With Lenski and a colleague, Turner used plasmids as models to test the theorized systematic trade-off between infectious and intergenerational modes of parasite transmission .
- In 2016, he and his group isolated from a Connecticut pond a lytic phage, OMKO1, which assaults the widespread multidrug-resistant pathogen Pseudomonas aeruginosa .
- at Imperial College London, where his sponsors embody John Warner, Stephen Durham and Gideon Lack.
Turner’s analysis regularly makes use of microbes as mannequin techniques to test evolutionary and ecological theories. With Lenski and a colleague, Turner used plasmids as fashions to test the theorized systematic commerce-off between infectious and intergenerational modes of parasite transmission . The researchers confirmed that infectious parasites cannot evolve to concurrently maximize horizontal and vertical transfers between hosts.